Cover Story: “Magical Mystery Cure”—Danielle Egan on the bizarre resurgence of psychosurgery to treat depression and OCD. Andre Mayer talks to transhumans in “The Great Byte Hope”. And, the winner of our 2004 prize for creative non-fiction, “Blood Oranges” by Munju Ravindra. Plus, reviews of new CDs by Neko Case and Stars, new fiction by M.A.C. Farrant, and way more. On newsstands January 2005—order now!